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Related Experiment Videos

Clonidine for smoking cessation

A Nana1, R Praditsuwan

  • 1Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
|April 8, 1998
PubMed
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Clonidine did not improve smoking cessation success rates or reduce nicotine withdrawal symptoms in a 5-week trial. The study found no significant difference between clonidine and placebo groups for quitting smoking.

Area of Science:

  • Pharmacology
  • Addiction Medicine
  • Clinical Trials

Background:

  • Nicotine addiction is a significant public health concern.
  • Smoking cessation interventions aim to reduce withdrawal symptoms and improve quit rates.
  • Clonidine has been explored as a potential aid for smoking cessation.

Purpose of the Study:

  • To evaluate the efficacy of clonidine in reducing nicotine withdrawal symptoms.
  • To determine if clonidine increases the success rate of smoking cessation.
  • To assess the safety and side effects of clonidine in smoking cessation.

Main Methods:

  • A double-blind, randomized, placebo-controlled trial was conducted.
  • 114 subjects were divided into clonidine (n=58) and placebo (n=56) groups.

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  • Participants received counseling and behavioral modification alongside 300 micrograms of clonidine or placebo for 5 weeks.

    • Main Results:

    • Clonidine did not significantly reduce nicotine withdrawal symptoms compared to placebo.
    • The smoking cessation success rate at 5 weeks was similar between groups (50% for clonidine vs. 48% for placebo).
    • No significant side effects were observed with clonidine use.

    Conclusions:

    • Clonidine demonstrated no beneficial effect on smoking cessation success rates.
    • Clonidine did not effectively alleviate nicotine withdrawal symptoms in this study population.
    • Further research may be needed to explore alternative pharmacological interventions for smoking cessation.