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Effects of lormetazepam on glycemia and serum lipids in hyperlipidemic rats
1Department of Pharmacology, Faculty of Medicine, University of Oradea, Romania.
Acta Physiologica Hungarica
|January 1, 1997
Abstract:
Lormetazepam (N-methyllorazepam) administered intraperitoneally to rats rendered hyperlipidemic by Triton WR-1339 induced an elevation of blood glucose level at all investigated doses. It brought about significant reduction of serum total lipids, total cholesterol and triglycerides. The dose-response relationship was bell-shaped. However, it presented two peaks, differing from the responses to other benzodiazepines (BZD) which were characterized by only one peak.