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Sarcomas near extremity joints in adults
C P Karakousis1, K Kontzoglou, D Driscoll
1State University of New York at Buffalo, Millard Fillmore Health System, Roswell Park Cancer Institute, USA.
Journal of Surgical Oncology
|April 8, 1998
Summary
Resecting sarcomas near joints is challenging. This study found higher local recurrence and amputation rates for these tumors compared to general extremity sarcomas, though survival rates remain comparable.
Area of Science:
- Orthopedic Oncology
- Surgical Oncology
- Sarcoma Research
Background:
- Soft tissue sarcomas extending to or crossing joints present significant surgical resection challenges.
- Limited data exists on the specific outcomes for these complex cases.
Purpose of the Study:
- To determine the amputation and local recurrence rates for soft tissue sarcomas involving joints.
- To compare these rates with those of overall extremity sarcomas.
Main Methods:
- Retrospective review of 78 patients with sarcomas near joints and 215 patients with overall extremity sarcomas (1977-1994).
- Analysis of surgical treatments including local excision, wide excision, and amputation.
- Evaluation of adjuvant radiation therapy's impact on recurrence and outcomes.
Main Results:
- A 20% local recurrence rate was observed in sarcomas near joints.
- Amputation was ultimately required in 27% of patients for disease control.
- Survival rates at 5 and 10 years were 68% and 60%, respectively, comparable to overall extremity sarcoma series.
Conclusions:
- Soft tissue sarcomas involving joints exhibit higher local recurrence and amputation rates than general extremity sarcomas.
- Despite higher local control rates, survival outcomes remain similar to broader extremity sarcoma populations.
- Multivariate analysis indicated tumor grade and size significantly impact survival.