Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Psychiatric genetics: search for phenotypes

M Leboyer1, F Bellivier, M Nosten-Bertrand

  • 1Service de psychiatrie adulte, Hôpital Pitié-Salpétrière, Paris, France.

Trends in Neurosciences
|April 8, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Family History and Solar Insolation in Bipolar I Disorder.

Acta psychiatrica Scandinavica·2026
Same author

Association Between Metabolic Syndrome, Obesity, and Cognitive Performances in Individuals With Bipolar Disorders: Cross-Sectional and Longitudinal Analyses in the FACE-BD Cohort.

Acta psychiatrica Scandinavica·2025
Same author

Functioning and neurocognition in very early and early-life onset bipolar disorders: the moderating role of bipolar disorder type.

European child & adolescent psychiatry·2024
Same author

Incidence and predictors of metabolic syndrome onset in individuals with bipolar disorders: A longitudinal study from the FACE-BD cohort.

Acta psychiatrica Scandinavica·2024
Same author

Methylomic biomarkers of lithium response in bipolar disorder: a clinical utility study.

International journal of bipolar disorders·2023
Same author

Telomere length and mitochondrial DNA copy number in bipolar disorder: identification of a subgroup of young individuals with accelerated cellular aging.

Translational psychiatry·2022

Psychiatric genetics research needs better phenotypic descriptions. Candidate symptom and endophenotype approaches can identify homogeneous disease forms and vulnerability traits, improving results in complex disease studies.

Area of Science:

  • Psychiatric genetics
  • Genetic epidemiology
  • Molecular biology

Background:

  • Progress in molecular biology and genetic epidemiology has outpaced phenotypic description in psychiatric genetics.
  • Classical nosological approaches have limited success in identifying homogeneous disease forms.

Purpose of the Study:

  • To propose candidate symptom and endophenotype approaches for more effective psychiatric genetics research.
  • To highlight the potential of these strategies in identifying homogeneous disease forms and vulnerability traits.
  • To bridge the gap between clinical and experimental approaches in psychiatry.

Main Methods:

  • Reviewing successful applications of candidate symptom and endophenotype approaches in complex diseases.
  • Focusing on identifying sub-clinical traits in relatives (endophenotypes).

Related Experiment Videos

  • Utilizing specific symptoms within affected subjects (candidate symptoms).

    • Main Results:

    • Candidate symptom and endophenotype approaches have shown success in other complex diseases.
    • These methods can identify more homogeneous disease subtypes.
    • Focusing on vulnerability traits can redefine traditional psychiatric syndromes.

    Conclusions:

    • Improved phenotypic description through candidate symptom and endophenotype approaches is crucial for psychiatric genetics.
    • These strategies offer a promising path to more robust and reproducible findings.
    • Redefining psychiatric syndromes based on vulnerability traits can enhance clinical and experimental integration.