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Pathological versus physiological left ventricular hypertrophy: a review

P A Richey¹, S P Brown

¹Department of Pediatrics and the Crippled Children's Foundation Research Center, University of Tennessee, Memphis 38103, USA.

Journal of Sports Sciences

|April 8, 1998

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Left ventricular hypertrophy is a risk for heart events, but its causes and whether it’s quantity or quality that matters are unclear. This review explores pathological and physiological states, patterns, and biochemical factors influencing this condition.

Area of Science:

Cardiology
Pathophysiology
Biochemistry

Background:

Left ventricular hypertrophy (LVH) is an independent risk factor for cardiovascular morbid events.
Primary mechanisms stimulating LVH remain largely unknown.
Conflicting theories exist regarding LVH as a continuous variable versus a risk determined by myocardial structure and function.

Purpose of the Study:

To review pathological and physiological states of left ventricular hypertrophy.
To examine hypertrophy patterns and their structural and functional characteristics.
To discuss biochemical factors influencing myocardial remodeling in LVH.

Main Methods:

Literature review of epidemiological and morphological studies.
Analysis of criteria for pathological and physiological LVH.

Related Experiment Videos

Exploration of myocardial adaptations to imposed loads.

Main Results:

Hemodynamic overloading is not the sole determinant of left ventricular structure and function in hypertensive patients.
Pathological and physiological LVH states are defined by imposed load and myocardial adaptations.
Myocardial quality and function, not just mass, are implicated in cardiovascular risk.

Conclusions:

Understanding the diverse states, patterns, and biochemical influences of LVH is crucial for assessing cardiovascular risk.
Further research into the primary mechanisms of LVH is warranted.
The role of myocardial structure and function, beyond mass, requires further elucidation.