Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

CD1.1 expression by mouse antigen-presenting cells and marginal zone B cells

J H Roark1, S H Park, J Jayawardena

  • 1Department of Molecular Biology, Princeton University, NJ 08544, USA.

Journal of Immunology (Baltimore, Md. : 1950)
|April 8, 1998
PubMed
Summary

Mouse CD1.1, a surface glycoprotein, is expressed on immune cells like dendritic cells and B cells. It likely presents antigens to T cells, potentially aiding innate immune responses against pathogens.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long-term quality of life in patients with vestibular schwannoma managed with microsurgery.

The Journal of laryngology and otology·2019
Same author

Psychosine variants as antigens for natural killer T cells.

Chemical science·2017
Same author

A peptide-free, liposome-based oligosaccharide vaccine, adjuvanted with a natural killer T cell antigen, generates robust antibody responses <i>in vivo.</i>

Chemical science·2014
Same author

Time to viral load suppression in antiretroviral-naive and -experienced HIV-infected pregnant women on highly active antiretroviral therapy: implications for pregnant women presenting late in gestation.

BJOG : an international journal of obstetrics and gynaecology·2013
Same author

Transcription factors and th17 cell development in experimental autoimmune encephalomyelitis.

Critical reviews in immunology·2013
Same author

Expression and interdependencies of pluripotency factors LIN28, OCT3/4, NANOG and SOX2 in human testicular germ cells and tumours of the testis.

International journal of andrology·2011

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • CD1.1 is an MHC class I-like molecule recognized by NK1.1+ T cells.
  • NK1.1+ T cells are a subset of alpha beta T cells that produce cytokines like IL-4 and IFN-gamma.

Purpose of the Study:

  • To characterize CD1.1 biochemically and monitor its surface expression.
  • To understand the function of CD1.1 in immune responses.

Main Methods:

  • Generation of nine monoclonal antibodies (mAbs) against CD1.1.
  • Biochemical characterization and surface expression analysis of CD1.1.
  • T cell hybridoma assays to study CD1.1 recognition.

Main Results:

  • CD1.1 is a heavily glycosylated protein associated with beta2-microglobulin.

Related Experiment Videos

  • Multiple T cell receptors bind to the same region on CD1.1.
  • CD1.1 is primarily expressed on dendritic cells, B cells, and macrophages, notably splenic marginal zone B cells.

    • Conclusions:

    • CD1.1 may function in antigen presentation to T helper cells.
    • CD1.1 might recruit innate immune help from cytokine-producing T cells to antigen-presenting cells.
    • This interaction could be crucial in the early stages of immune responses to microbial pathogens.