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A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry
Published on: June 5, 2019
Platelet activation in patients with sickle cell disease
T Wun1, T Paglieroni, A Rangaswami
1Division of Hematology and Oncology, UC Davis School of Medicine, Sacramento Medical Foundation Center for Blood Research, California 95817, USA.
British Journal of Haematology
|April 8, 1998
Summary
Platelets are activated in sickle cell disease (SCD), contributing to vascular issues. This study found increased platelet activation markers and microparticles in SCD patients compared to controls.
Area of Science:
- Hematology
- Vascular Biology
- Immunology
Background:
- Sickle cell anemia (SCA) involves vascular occlusion and vasculopathy, leading to significant morbidity.
- Platelets are implicated as potential contributors to the vasculopathy observed in SCA.
Purpose of the Study:
- To investigate evidence of platelet activation in patients with sickle cell disease (SCD).
- To compare platelet activation markers in SCD patients with healthy controls.
Main Methods:
- Flow cytometry was used to analyze platelet activation.
- Fluorescent-labeled monoclonal antibodies detected activation-dependent antigens on platelets.
- Platelet microparticles were quantified in SCD patients.
Main Results:
- Patients with SCD exhibited increased expression of activation-dependent antigens on their platelets compared to controls.
- SCD patients showed higher levels of circulating platelet microparticles.
- These findings indicate heightened platelet activation in individuals with SCD.
Conclusions:
- Platelet activation is a significant feature in patients with sickle cell disease.
- The role of platelet activation in the pathophysiology of SCD is an area of ongoing research.
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