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Cardiorespiratory reflexes in mice

J F Paton1, J W Butcher

  • 1Department of Physiology, School of Medical Sciences, University of Bristol, UK. julian.f.r.paton@bris.ac.uk

Journal of the Autonomic Nervous System
|April 8, 1998
PubMed
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This study compares cardiorespiratory reflexes in anesthetized mice and a working heart-brainstem preparation (WHBP). Both models show similar reflex responses, validating the WHBP for studying the cardiorespiratory system.

Area of Science:

  • Physiology
  • Cardiovascular Research
  • Neuroscience

Background:

  • Mice are valuable experimental models due to transgenic strains.
  • Understanding cardiorespiratory control is crucial for physiological research.

Purpose of the Study:

  • To compare cardiorespiratory reflex responses in two mouse preparations: in vivo anesthetized and working heart-brainstem preparation (WHBP).
  • To assess the suitability of the WHBP as a model for studying central cardiorespiratory control mechanisms.

Main Methods:

  • Qualitative comparison of cardiorespiratory reflexes.
  • Stimulation of baroreceptors, pulmonary vagal C fibres, cardiac receptors, and peripheral chemoreceptors.
  • Utilized in vivo urethane-anesthetized mice and a working heart-brainstem preparation (WHBP).

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Main Results:

  • Both preparations exhibited atropine-sensitive bradycardia and depressed ventilation upon stimulation of baroreceptors, pulmonary C fibres, and cardiac receptors.
  • The WHBP demonstrated similar reflex bradycardia and respiratory responses.
  • Peripheral chemoreceptor stimulation in the WHBP induced atropine-sensitive bradycardia and altered respiratory patterns.

Conclusions:

  • Cardiorespiratory reflex responses in mice are comparable to those in other species.
  • The working heart-brainstem preparation (WHBP) is an adequate model for investigating central cardiorespiratory control due to its similar reflex performance to in vivo preparations.