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[Large granular lymphocytic leukemia]

S Berentsen1, O Bruserud, E Ulvestad

  • 1Medisinsk avdeling, Fylkessjukehuset i Haugesund.

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
|April 9, 1998
PubMed
Summary
This summary is machine-generated.

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Large granular lymphocyte leukaemia (LGL leukaemia) is a rare T-cell chronic lymphocytic leukaemia. Diagnosis involves identifying CD3+, CD8+, CD57+ lymphocytes in patients with neutropenia and rheumatic symptoms.

Area of Science:

  • Hematology
  • Immunology
  • Oncology

Background:

  • Large granular lymphocyte leukaemia (LGL leukaemia) is a rare, chronic lymphoproliferative bone marrow disorder.
  • It is considered a subtype of chronic T-cell lymphocytic leukaemia (T-CLL).

Observation:

  • Three patients presented with chronic disease, neutropenia, and relative lymphocytosis.
  • All patients exhibited an expansion of mature lymphocytes with a CD3+, CD8+, CD57+ immunophenotype.
  • Two patients had recurrent infections, and all three showed serological findings compatible with rheumatic disease, including rheumatoid arthritis in two.

Findings:

  • LGL leukaemia is characterized by lymphocytosis, neutropenia, and an increased susceptibility to infection.
  • Associated autoimmune manifestations, such as rheumatoid arthritis, are frequently observed.

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Implications:

  • LGL leukaemia should be considered in patients with chronic neutropenia and lymphocytosis, especially with concurrent rheumatic symptoms.
  • Flow cytometric immunophenotyping is a sensitive diagnostic tool for LGL leukaemia.