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Adenosine and migraine

R Guieu1, C Devaux, H Henry

  • 1UMR CNRS 6560, Faculté de Médecine Secteur Nord, Marseille, France.

The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
|April 9, 1998
PubMed
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Migraine headaches show increased adenosine levels, potentially contributing to pain. Adenosine also affects serotonin uptake by platelets, suggesting adenosine antagonists may help treat migraines.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Vascular Biology

Background:

  • Adenosine is a vasodilator regulating cerebral and meningeal blood flow.
  • Adenosine may play a role in migraine pathophysiology.
  • Intravenous adenosine has been reported to trigger migraine attacks.

Purpose of the Study:

  • Investigate circulating adenosine levels in migraine patients.
  • Explore adenosine's interaction with serotonin pathways.
  • Assess the potential of adenosine antagonists in migraine treatment.

Main Methods:

  • Measured circulating adenosine levels in migraineurs during crises and remission.
  • Compared adenosine levels to a control group.
  • Examined adenosine's effect on platelet serotonin uptake and release.

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Main Results:

  • Circulating adenosine levels were significantly increased (68%) during migraine headaches.
  • Adenosine activation of A2 receptors dose-dependently inhibited platelet serotonin uptake.
  • This inhibition may contribute to serotonin elimination in migraine sufferers.

Conclusions:

  • Elevated adenosine levels during migraine headaches may contribute to cephalalgia.
  • Adenosine-induced inhibition of serotonin uptake could be a mechanism in migraine.
  • Adenosine antagonists may offer a complementary therapeutic strategy for migraine.