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Blood flow differences between leuko-araiosis with and without lacunar infarction
M Oishi1, Y Mochizuki, T Takasu
1Department of Neurology, Nihon University School of Medicine, Tokyo, Japan.
Summary
Leuko-araiosis with lacunar infarction shows reduced cerebral blood flow and reactivity compared to leuko-araiosis without infarction. This suggests more severe arteriolosclerosis and higher hypertension rates in patients with lacunar infarction.
Area of Science:
- Neurology
- Vascular Neurology
- Neuroimaging
Background:
- Leuko-araiosis is a common finding in aging brains.
- Lacunar infarction is a type of stroke caused by blockages in small arteries.
Purpose of the Study:
- To investigate differences in regional cerebral blood flow (rCBF) and cerebrovascular acetazolamide reactivity (CVAR).
- To compare these parameters between patients with leuko-araiosis with and without lacunar infarction.
Main Methods:
- Stable xenon computed tomography (CT) was used to measure rCBF.
- CVAR was assessed by measuring rCBF before and after acetazolamide injection.
- Three groups were studied: leuko-araiosis with lacunar infarction, leuko-araiosis without lacunar infarction, and controls.
Main Results:
- Reduced rCBF and CVAR were observed in leuko-araiosis and lacunar areas compared to cerebral white matter.
- Patients with leuko-araiosis and lacunar infarction showed significantly lower rCBF and CVAR in cortical and white matter areas compared to the other two groups.
- Cerebral blood flow and reactivity were significantly lower in leuko-araiosis with lacunar infarction.
Conclusions:
- Leuko-araiosis with lacunar infarction is associated with more severe arteriolosclerosis.
- A higher rate of hypertension is observed in leuko-araiosis with lacunar infarction compared to leuko-araiosis without lacunar infarction.