Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Retro-orbital autoimmunity

A E Heufelder1

  • 1Medizinische Klinik, Klinikum Innenstadt, Ludwig-Maximilians-University, München, Germany.

Bailliere'S Clinical Endocrinology and Metabolism
|April 9, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[New therapeutic options in obesity].

MMW Fortschritte der Medizin·2003
Same author

Serum levels of tumor necrosis factor-alpha, soluble intercellular adhesion molecule-1, soluble vascular cell adhesion molecule-1, and soluble interleukin-1 receptor antagonist in patients with thyroid eye disease undergoing treatment with somatostatin analogues.

Thyroid : official journal of the American Thyroid Association·2002
Same author

Pathogenesis of ophthalmopathy in autoimmune thyroid disease.

Reviews in endocrine & metabolic disorders·2001
Same author

[Interactions of fibroblasts, adipocytes and immunocompeent cells in the pathogenesis of endocrine ophthalmopathy].

Acta medica Austriaca·2001
Same author

Sodium iodide symporter-based strategies for diagnosis and treatment of thyroidal and nonthyroidal malignancies.

Thyroid : official journal of the American Thyroid Association·2001
Same author

Autoimmunity involving the human sodium/iodide symporter: fact or fiction?

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association·2001
Same journal

Phytoestrogen content in foods.

Bailliere's clinical endocrinology and metabolism·1999
Same journal

Soyfoods, isoflavones and risk of colonic cancer: a review of the in vitro and in vivo data.

Bailliere's clinical endocrinology and metabolism·1999
Same journal

Experimental studies on lignans and cancer.

Bailliere's clinical endocrinology and metabolism·1999
Same journal

Reproductive actions of phytoestrogens.

Bailliere's clinical endocrinology and metabolism·1999
Same journal

Phytoestrogens and inhibition of angiogenesis.

Bailliere's clinical endocrinology and metabolism·1999
Same journal

Phytoestrogens and diseases of the prostate gland.

Bailliere's clinical endocrinology and metabolism·1999
See all related articles

Graves' ophthalmopathy arises from genetic and environmental factors, involving complex orbital immune processes. Recent research deepens understanding of retro-orbital autoimmunity, focusing on T-cells and antigens in autoimmune thyroid disease.

Area of Science:

  • Immunology
  • Endocrinology
  • Ophthalmology

Background:

  • Graves' ophthalmopathy (GO) etiology remains unclear, likely involving genetic predisposition and environmental triggers.
  • The disease involves a complex interplay of genetic factors (e.g., human leukocyte antigens) and environmental influences.
  • Significant advancements in understanding the initiating events of orbital immune processes in autoimmune thyroid disease have been made.

Purpose of the Study:

  • To review recent developments in retro-orbital autoimmunity.
  • To discuss new insights into orbital T-cell repertoires and candidate orbital antigens.
  • To explore the role of target and effector cells in extrathyroidal manifestations of autoimmune thyroid disease.

Main Methods:

  • Review of recent scientific literature on Graves' ophthalmopathy.

Related Experiment Videos

  • Analysis of new findings concerning orbital immune processes.
  • Focus on T-cell repertoires, antigens, and cellular interactions in retro-orbital autoimmunity.

    • Main Results:

    • Progress in understanding the initiating events of orbital immune processes in autoimmune thyroid disease.
    • Extended knowledge of effector and target cells involved in the orbital immune process.
    • New developments regarding orbital T-cell repertoires and candidate antigens.

    Conclusions:

    • Graves' ophthalmopathy pathogenesis is multifactorial, involving genetic susceptibility and environmental factors.
    • The orbital immune process, once initiated, appears to perpetuate independently.
    • Further research into retro-orbital autoimmunity, T-cells, and antigens is crucial for understanding extrathyroidal manifestations.