Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Thyroxine suppression therapy in Graves' disease

¹Royal Infirmary NHS Trust, Edinburgh, Scotland.

Bailliere'S Clinical Endocrinology and Metabolism

|April 9, 1998

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Core genome multi-locus sequence typing as an essential tool in a high-cost livestock-associated meticillin-resistant Staphylococcus aureus CC398 hospital outbreak.

The Journal of hospital infection·2019

Same author

Toxicity and efficacy of lomustine and bevacizumab in recurrent glioblastoma patients.

Journal of neuro-oncology·2018

Same author

An atypical cause of trigeminal neuralgia and panhypopituitarism.

The British journal of radiology·2010

Same author

Neuropsychological functioning, illness perception, mood and quality of life in chronic fatigue syndrome, autoimmune thyroid disease and healthy participants.

Psychological medicine·2009

Same author

Atmospheric chemistry of a model biodiesel fuel, CH3C(O)O(CH2)2OC(O)CH3: kinetics, mechanisms, and products of Cl atom and OH radical initiated oxidation in the presence and absence of NOx.

The journal of physical chemistry. A·2007

Same author

Atmospheric chemistry of CF3CH=CH2 and C4F9CH=CH2: products of the gas-phase reactions with Cl atoms and OH radicals.

The journal of physical chemistry. A·2007

A novel Graves' disease treatment showed a low relapse rate in Japan but failed to replicate in Scotland. Current evidence does not support adopting this new

Area of Science:

Endocrinology
Thyroidology
Immunology

Background:

Graves' disease is an autoimmune disorder causing hyperthyroidism.
The 'block-and-replace' regime is a treatment strategy for Graves' disease.
A novel modification of this regime reported exceptionally low relapse rates.

Purpose of the Study:

To evaluate the efficacy of a novel 'block-and-replace' regime for Graves' hyperthyroidism.
To compare the novel regime with conventional treatments.
To investigate factors influencing treatment outcomes.

Main Methods:

A Japanese study reported a novel 'block-and-replace' regime.
Thyroxine was continued alone after combination therapy cessation.
A Scottish study attempted to replicate these findings.

Related Experiment Videos

Main Results:

The Japanese study reported a relapse rate of less than 2%.
A large Scottish study failed to confirm the benefit of the novel treatment.
Discrepant results between studies suggest potential influences of race and iodine intake.

Conclusions:

The novel 'block-and-replace' regime's efficacy is not confirmed in a Scottish cohort.
Elevated TSH in control groups might affect remission rates.
There is currently no strong reason to adopt the novel regime, particularly in Caucasian populations.