[An experimental model of enteric klebsiellosis]

Acute enteric infection was reproduced in rabbits, used as an experimental model, receiving Aspergillus flavus metabolites with food for 15 days and inoculated rectally with enterotoxigenic strain Klebsiella pneumoniae K24 6723. Pathomorphological study revealed the penetration of Klebsiella into microplicate cells of the intestinal epithelium, the proliferation of bacteria in the lamina propria and in the cupolas of Peyer's patches, as well as in phagolysosomes of leukocytes and macrophages. The lesion of the mucous membrane in both large and small intestine, accompanied by the hyperplasia of lymphoid follicles, was noted. As a rule, surface epithelium was dystrophically changed and peeled off into the lumen of the intestine. The specificity of such lesion was confirmed by the detection of Klebsiella in Coons' direct immunofluorescence test. The experimental model confirmed the role of a decrease in immunological protective reactions of the body, caused the action of A.flavus metabolites, in the development of the infectious process, initiated by opportunistic enterobacteria.