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[Hep-A-in-Vac, a Russian cultured concentrated inactivated vaccine against hepatitis A]
M A Gorbunov1, L I Pavlova, S D Rozhkov
1Tarasevich State Research Institute for Standartization and Control of Medical Biological Preparations, Moscow, Russia.
Abstract:
The results of the study of the reactogenicity, safety and immunological activity of Russian cultural vaccine against hepatitis A are presented. The vaccine was found to have specific safety, moderate reactogenicity and pronounced immunological activity. In addition, the study of the prophylactic efficiency of the vaccine in the pre-epidemic period of the outbreak of hepatitis A morbidity in a group exceeding 14,000 adults was carried out. The study revealed high prophylactic efficiency of the vaccine (its efficiency rate was equal to 97.7%). On the basis of materials thus obtained vaccine "Hep-A-in-Vac" was recommended for use in medical practice for the prophylaxis of hepatitis A among adults.