[Effect of striatectomy on the course of corazole seizures in rats]

Behaviouristic and EEG-manifestations of pentylentetrazol convulsions were studied in unrestrained rats with preliminarily destroyed striatum. The operation caused no significant disturbance of the appearance of the spike-wave activity, but sharply inhibited provocation of myoclonic and their change into tonico-clonic convulsions. Besides, there was an increase in the threshold, the duration and the severity of the attack; an epileptic status was even observed in 50% of these rats. Striatectomy eliminated the action of catecholaminergic agents (apomorphine, DOPA, haloperidol, chlorpromazine) on the thresholds of myclonic jerks and the attack.