E1Age and the development of coronary insufficiency under the influence of vasopressin

Experimental results showed that the ECG changes (elevation of T wave, a shift of the S-T segment and disturbances of the atrio-ventricular conduction) under the effect of vasopressin occurred in rats aged 24-26 months after lower doses of vasopressin than in the animals aged 10-12 months. With the administration of the same doses coronary insufficiency was more pronounced in the old animals (more frequent disturbances of the atrio-ventricular conduction, grade II or III, and greater derangement of general hemodynamics).