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Experimental Infection with Listeria monocytogenes as a Model for Studying Host Interferon-γ Responses
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Published on: November 16, 2016

[Enhancement of the immune response following immunization with L1210 cells preliminarily incubated with interferon]

S V Skurkovich, I A Kalinina, E I Eremkina

    Biulleten' Eksperimental'Noi Biologii I Meditsiny
    |June 1, 1976
    PubMed

    A single intraperitioneal injection of L 1210 cells preincubated in interferon or in "false interferon" was given to mice. These mice were sacrificed on the 10th day, and cytotoxicity of the sera against the L 1210 leukemic cells vas determined in the microcytotoxic test (modification of Terasaki's method). Leukemic cells treated with interferon before the immunization caused a more pronounced immune response in comparison with the cells treated under the same conditions with "false interferon". By the results of cytotoxic reaction immune response was enhanced 2-4-fold.

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