[Adrenalectomized mice as an experimental model for studying the biological activity of immune complexes]

Adrenalectomized mice may develop local (skin) and systemic reactions on the introduction of immune complexes formed in vitro. Regularities in respect to the composition of immune complexes (in which their general, toxic, action and the capacity to produce local reactions was expressed) were revealed. Treatment with agents depressing the anaphylactic reaction (cortisone, antihistaminic drugs, anesthetics) diminished the reactions to the immune complex. Local reaction to the immune complex decreased in animals with artificially-induced fall of the blood complement level.