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[A rapid method standardizing cholagogue substances on mice]

M D Litvinchuk

    Biulleten' Eksperimental'Noi Biologii I Meditsiny
    |July 1, 1976
    PubMed
    Summary
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    [Determination of mebethisol and ways of its elimination from the body].

    Vrachebnoe delo·1977

    Researchers developed a quick method to measure how well substances like insulin and mebethizol stimulate bile production in mice. This technique aids in the rapid pharmacological screening of potential drugs.

    Area of Science:

    • Pharmacology
    • Drug Discovery
    • Biochemistry

    Context:

    • Assessing the efficacy of cholagogue agents is crucial in drug development.
    • Existing methods for quantitative assessment of bile accumulation can be time-consuming.
    • There is a need for rapid screening tools in pharmacological research.

    Purpose:

    • To describe a rapid method for the quantitative assessment of specific cholagogue activity.
    • To evaluate the bile-accumulating effects of insulin, chologon, and mebethizol in mice.
    • To establish a reliable technique for pharmacological screening.

    Summary:

    • A novel, rapid method was developed to assess the cholagogue activity of substances by measuring bile accumulation in mouse gall bladders.
    • The technique involves weighing the gall bladder with and without bile to quantify the amount of bile accumulated over a specific period.

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  • The study successfully demonstrated the method's utility in evaluating the effects of insulin, chologon, and mebethizol.

    • Impact:

    • This method provides a faster and more efficient approach for the pharmacological screening of cholagogue agents.
    • It can accelerate the early stages of drug discovery for compounds influencing bile production.
    • The technique is applicable to a broader range of substances requiring assessment of their impact on bile accumulation.