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Related Experiment Videos

Transcutaneous access to retrograde axonal flow

P D Costas1, T D Sabin, K K Wang

  • 1Department of Plastic and Reconstructive Surgery, Lahey Hitchcock Medical Center, Burlington, Massachusetts 01805, USA.

Muscle & Nerve
|April 9, 1998
PubMed
Summary
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Dimethyl sulfoxide (DMSO) enabled transcutaneous entry and retrograde transport of fluorescent tracers into rat dorsal root ganglia. This method bypassed aqueous absorption, suggesting potential pathways for nervous system entry of various agents.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Toxicology

Background:

  • The nervous system is protected by barriers that limit the entry of substances.
  • Understanding pathways for substance entry is crucial for neuroscience and medicine.

Purpose of the Study:

  • To investigate the potential for transcutaneous delivery of substances to the nervous system using dimethyl sulfoxide (DMSO).
  • To demonstrate retrograde neuronal transport of a fluorescent tracer applied topically.

Main Methods:

  • A fluorescent tracer was dissolved in DMSO and applied topically to the hind limb of rats.
  • The dorsal root ganglia were examined for the presence of the fluorescent tracer.

Main Results:

  • Fluorescent tracer was detected in the dorsal root ganglia, indicating transcutaneous entry and retrograde transport.

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  • No evidence of aqueous absorption of the tracer by neuronal tissue was found.

    • Conclusions:

    • Dimethyl sulfoxide (DMSO) can facilitate the transcutaneous entry and retrograde transport of substances into the nervous system.
    • This mechanism may be relevant for the entry of toxins, viruses, chemicals, and therapeutic agents into neural tissues.