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Muscle fiber type-specific myofibrillar actomyosin Ca2+ ATPase activity in multiple sclerosis
M J Castro1, J A Kent-Braun, A V Ng
1Department of Exercise Science, University of Georgia, Athens 30602, USA.
Muscle & Nerve
|April 9, 1998
Abstract:
Biopsies of tibialis anterior muscle were analyzed to determine if increased energy demand of contraction, as indirectly reflected by myofibrillar actomyosin Ca2+ ATPase (qATPase) activity, contributes to symptomatic fatigue in multiple sclerosis (MS). qATPase activity showed a fiber-type effect, IIax > IIa > I. Fiber-type qATPase activity, however, was not different between MS patients and healthy controls. We suggest that fatigue in MS does not reflect increased energy demand of contraction.
Keywords:
Non-programmatic