Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Normal blood-glucose concentration which range for what?

B Grenier1

  • 1Faculté de Médecine de Tours.

Diabetes & Metabolism
|April 16, 1998
PubMed
Summary

Defining biological normality requires considering clinical implications. Abnormal variations are identified by their risk of future ailments, guiding medical strategy for patient benefit.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intrahepatic cholangiocarcinoma trends and treatment lines: real-world evidence from the French National Hospital Discharge database.

ESMO gastrointestinal oncology·2026
Same author

Socioeconomic determinants of vaccination against pneumococcus in 763 945 patients with heart failure.

ESC heart failure·2025
Same author

[EASYSCAN: French pilot study for securing drug administration by barcode reading].

Annales pharmaceutiques francaises·2021
Same author

Combined SERS/DFT studies of push-pull chromophore self-assembled monolayers: insights into their surface orientation.

Physical chemistry chemical physics : PCCP·2019
Same author

Enzymatic hydrolysis of fumonisins in the gastrointestinal tract of broiler chickens.

Poultry science·2017
Same author

Prevalence and effects of mycotoxins on poultry health and performance, and recent development in mycotoxin counteracting strategies.

Poultry science·2015

Area of Science:

  • Clinical biochemistry
  • Medical diagnostics
  • Preventive medicine

Background:

  • Normality in biological parameters can be defined statistically ('isolated') or clinically ('correlated').
  • The 'correlated' definition considers variations abnormal if they pose a risk for future health issues.
  • This pragmatic approach links the upper limit of normal/abnormal variations to expected medical benefits.

Purpose of the Study:

  • To explore two definitions of biological normality: 'isolated' and 'correlated'.
  • To emphasize the importance of clinical relevance in defining abnormal biological variations.
  • To highlight how the choice of parameter limits influences diagnostic test effectiveness.

Main Methods:

  • Statistical procedures for determining 'isolated' normality boundaries.
  • Clinical and predictive assessments for 'correlated' normality, focusing on future health risks.
  • Evaluation of diagnostic test discrimination based on chosen parameter values.

Main Results:

  • The 'correlated' definition of normality is pragmatic, linking abnormal variations to potential future ailments.
  • The effectiveness of diagnostic tests hinges on the chosen parameter value for risk discrimination.
  • Setting normal/abnormal limits should align with preventive and therapeutic goals.

Conclusions:

  • Defining biological normality requires a clinical perspective, considering potential health hazards.
  • Medical strategy and patient benefit are paramount when establishing normal/abnormal variation limits.
  • Parameter limits for diagnostic tests, such as glycaemia, must be set based on intended preventive or therapeutic interventions.

Related Experiment Videos