Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

HLA and elephantiasis revisited

M Yazdanbakhsh1, K Abadi, M de Roo

  • 1Department of Parasitology, University Hospital Leiden, The Netherlands.

European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics
|April 16, 1998
PubMed
Summary

Human leukocyte antigen (HLA) class II alleles were not strongly associated with elephantiasis progression in Brugian filariasis. This study could not confirm earlier findings suggesting a link between HLA-DR and -DQ alleles and disease resistance.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ultrastructural Evidence for a Role of Astrocytes and Glycogen-Derived Lactate in Learning-Dependent Synaptic Stabilization.

Cerebral cortex (New York, N.Y. : 1991)·2019
Same author

Palmitoylation of cdc42 Promotes Spine Stabilization and Rescues Spine Density Deficit in a Mouse Model of 22q11.2 Deletion Syndrome.

Cerebral cortex (New York, N.Y. : 1991)·2016
Same author

Fibril growth and seeding capacity play key roles in α-synuclein-mediated apoptotic cell death.

Cell death and differentiation·2015
Same author

[Endobronchial ultrasound-guided transbronchial needle aspiration for lung cancer diagnosis and staging in 179 patients].

Revista portuguesa de pneumologia·2013
Same author

Budget impact analysis of a new prostate cancer risk index for prostate cancer detection.

Prostate cancer and prostatic diseases·2011
Same author

Nutritional diagnosis obtained by subjective global assessment in surgical patients and occurrence of post operative complications.

Nutricion hospitalaria·2009

Area of Science:

  • Immunogenetics
  • Tropical Medicine
  • Human Genetics

Background:

  • Brugian filariasis is a parasitic disease endemic in tropical regions.
  • Previous research suggested a link between specific human leukocyte antigen (HLA) class II alleles and resistance to developing elephantiasis.
  • This association was observed in a case-control study in Indonesia.

Purpose of the Study:

  • To investigate the association between HLA class II alleles and the development of elephantiasis in Brugian filariasis.
  • To validate or refute previous findings suggesting HLA-DR and -DQ alleles confer resistance to elephantiasis.
  • To provide anthropological reference data for a South Sulawesi Indonesian population.

Main Methods:

  • A case-control study was conducted in a South Sulawesi Indonesian population.

Related Experiment Videos

  • Human leukocyte antigen (HLA) class II alleles were analyzed in individuals with Brugian filariasis.
  • Statistical analysis was performed to determine associations between specific HLA alleles and disease progression.

    • Main Results:

    • The study could not confirm the previously suggested association between HLA-DR and -DQ alleles and resistance to elephantiasis.
    • No strong association was found between HLA class II alleles and the progression of Brugian filariasis to elephantiasis in this population.
    • Complete data were collected for anthropological reference.

    Conclusions:

    • HLA-DR and -DQ alleles are not strongly associated with the progression to elephantiasis in Brugian filariasis in the studied Indonesian population.
    • The findings do not support the hypothesis that specific HLA class II alleles confer significant resistance to elephantiasis development.
    • Further research may be needed to explore other genetic or environmental factors influencing filariasis progression.