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Actual blood pressure control: are we doing things right?
1Department of Internal Medicine, Hospital Clinic, University of Barcelona, Spain.
Insights
Lowering blood pressure significantly reduces cardiovascular event risk. However, achieving target blood pressure remains a challenge, especially in elderly patients, often requiring combination therapy for effective hypertension management.
Area of Science:
- Cardiology
- Hypertension Research
- Public Health
Background:
- High blood pressure is a major risk factor for cardiovascular disease, including stroke and coronary events.
- Epidemiological studies and clinical trials demonstrate a direct correlation between elevated blood pressure and increased cardiovascular risk.
- Antihypertensive treatment aims to reduce morbidity and mortality, with significant risk reduction observed for even modest blood pressure lowering.
Purpose of the Study:
- To summarize the correlation between blood pressure and cardiovascular event risk.
- To highlight the challenges in achieving target blood pressure control in hypertensive patients.
- To discuss potential strategies for improving blood pressure management.
Main Methods:
- Review of epidemiological studies and randomized controlled trials on antihypertensive treatment.
- Analysis of survey data on blood pressure control rates in primary care and international studies.
- Consideration of preliminary reports on combination therapy for hypertension.
Main Results:
- A fall of 5-6 mmHg in diastolic blood pressure or 10 mmHg in systolic blood pressure reduces cerebrovascular event risk by 40% and coronary event risk by 15%.
- Blood pressure control rates below 140/90 mmHg are low, ranging from 13% to 26% in Spain and similar in other developed countries.
- Achieving target blood pressure, particularly systolic pressure, is difficult, especially in elderly patients on monotherapy.
Conclusions:
- Maximum tolerated blood pressure reduction is generally appropriate, though target levels require further consensus.
- Current blood pressure control rates are insufficient, indicating significant challenges in managing hypertension.
- Combined antihypertensive therapy, potentially using fixed-dose combinations, is often necessary to achieve target blood pressure and improve compliance.
Abstract:
CORRELATION BETWEEN BLOOD PRESSURE AND RISK OF CARDIOVASCULAR EVENTS: The goal of antihypertensive treatment is to reduce morbidity and mortality from cardiovascular disease associated with high blood pressure values. Epidemiological studies have demonstrated a direct correlation between the risk of stroke or coronary events and blood pressure values, and randomized controlled trials with antihypertensive drugs have shown that an average fall in diastolic blood pressure (DBP) of 5-6 mmHg [or in systolic blood pressure (SBP) of 10 mmHg] reduces the relative risk of cerebrovascular events by 40% and of coronary events by 15%. Thus, it would seem appropriate to achieve the maximum tolerated blood pressure reduction, although there is still no consensus on how far blood pressure should be lowered. PROBLEMS OF BLOOD PRESSURE CONTROL: Because the reduction in the absolute risk for a given level of blood pressure is higher in elderly patients and in those with multiple risk factors, the 1996 World Health Organization report recommends lowering blood pressure to below 140/90 mmHg in elderly patients, and suggests that it might be desirable to achieve blood pressure values of 120-130/80 mmHg in young patients with mild hypertension. Recent surveys in primary care centers in Spain show blood pressure control rates (blood pressure < 140/90 mmHg) ranging from 13 to 26%. These insufficient rates denote the particular difficulty of controlling SBP in an elderly population of patients with essential hypertension mainly treated in monotherapy schedules. The picture is similar in other developed countries. In a sample of 14,000 patients from Western European countries the Cardiomonitor survey showed control rates of 43% for DBP (< 90 mmHg) and 35% for SBP (< 140 mmHg). No more than 24% of treated hypertensive patients achieve the target (blood pressure < 140/90 mmHg) in the USA, and no more than 27% (DBP < 90 mmHg) in New Zealand. Preliminary reports from the Hypertension Optimal Treatment study indicate that in most patients combined therapy is required to achieve target blood pressure. Fixed combinations of synergistic antihypertensive drugs may help to improve both drug compliance and blood pressure control.