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Related Experiment Videos

Cat scratch disease in Greece

T Karpathios1, C Golphinos, P Psychou

  • 1Second Department of Paediatrics, P and A Kyriakou Children's Hospital, Athens, Greece.

Archives of Disease in Childhood
|April 16, 1998
PubMed
Summary

Indirect fluorescent antibody testing accurately diagnosed cat scratch disease in children. This Bartonella henselae antibody test is a valuable tool for confirming the infection in clinical settings.

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Area of Science:

  • Infectious Diseases
  • Immunology
  • Pediatrics

Background:

  • Cat scratch disease (CSD) is a bacterial infection caused by Bartonella henselae.
  • Diagnosis can be challenging, often relying on clinical presentation and serological tests.

Purpose of the Study:

  • To evaluate the utility of indirect fluorescent antibody (IFA) testing for diagnosing Bartonella henselae, B. quintana, and B. elizabethae infections in children with suspected CSD.
  • To assess the accuracy of clinical suspicion in diagnosing CSD in a pediatric outpatient setting.

Main Methods:

  • An indirect fluorescent antibody (IFA) test was performed on serum samples from 18 children with suspected CSD.
  • Samples were collected at admission, 15 days, and 6 months.
  • Diagnosis was confirmed by seroconversion, a fourfold change in antibody titer, or a single high antibody titer (>128).

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Main Results:

  • Diagnosis was confirmed in 15 out of 18 patients (83%).
  • Seroconversion or a fourfold antibody titer change to B. henselae confirmed diagnosis in 12 patients.
  • Three patients had a single high antibody titer (>128).
  • Common clinical manifestations included lymphadenopathy, with other reported symptoms like erythema nodosum, osteomyelitis, hepatitis, transverse myelitis, and granulomata.

Conclusions:

  • Clinical suspicion of CSD in a pediatric outpatient setting is highly accurate.
  • Indirect fluorescent antibody (IFA) testing for Bartonella henselae is a useful and effective diagnostic tool for confirming CSD.