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Inhibin secretion in the stallion

S Nagata1, Y I Miyake, Y Nambo

  • 1Laboratory of Racing Chemistry, Tokyo, Japan.

Equine Veterinary Journal
|April 16, 1998
PubMed
Summary

In stallions, inhibin is primarily produced by testicular Leydig and Sertoli cells. Plasma inhibin levels reflect testicular activity, making it a useful indicator of reproductive status.

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Area of Science:

  • Reproductive Endocrinology
  • Veterinary Physiology

Background:

  • Inhibin's physiological role in stallions was not well understood.
  • Investigating inhibin's source and function is crucial for understanding stallion reproductive physiology.

Purpose of the Study:

  • To determine the physiological role of inhibin in stallions.
  • To identify the cells responsible for inhibin secretion in the stallion testis.
  • To assess plasma inhibin as an indicator of reproductive activity.

Main Methods:

  • Validated a heterologous radioimmunoassay (RIA) for immunoreactive (ir)-inhibin.
  • Assessed bioactivity using an FSH suppression assay in rat pituitary cells.
  • Localized inhibin in testicular tissue via immunohistochemistry.

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Main Results:

  • Stallion plasma and testicular homogenates showed parallel dose-response curves in RIA and bioassays.
  • Bilateral gonadectomy led to decreased ir-inhibin and increased FSH/LH, indicating testicular origin.
  • Immunohistochemistry revealed inhibin in Leydig and Sertoli cells, with Leydig cells showing stronger staining.
  • Plasma ir-inhibin exhibited seasonal variation, correlating with testicular activity.

Conclusions:

  • The stallion testis is the primary source of circulating inhibin.
  • Leydig and Sertoli cells are the identified sources of testicular inhibin.
  • Plasma ir-inhibin is a reliable indicator of stallion reproductive activity throughout the year.