Electroanalytical study of nifedipine using activated glassy carbon electrode

Area of Science:

• Analytical Chemistry
• Electrochemistry
• Pharmaceutical Analysis

Background:

• Nifedipine is a widely used calcium channel blocker.
• Accurate quantification of nifedipine in pharmaceutical formulations is crucial for therapeutic efficacy and patient safety.
• Existing analytical methods may require complex procedures or lack sensitivity.

Purpose of the Study:

• To develop and validate a novel electrochemical method for the determination of nifedipine.
• To investigate the electrochemical behavior of nifedipine at a modified glassy carbon electrode.
• To apply the developed method for the analysis of nifedipine in commercial drug products.

Main Methods:

• Linear sweep voltammetry and cyclic voltammetry were employed.
• A glassy carbon electrode was activated using a new pre-treatment method.
• The influence of pH, concentration, and scan rate on nifedipine voltammograms was systematically studied.

Main Results:

• The electrochemical reduction and oxidation of nifedipine were successfully utilized for its determination.
• The method demonstrated quantitative analysis in the concentration ranges of 2 x 10(-5)-6 x 10(-4) M (reduction) and 8 x 10(-5)-1 x 10(-3) M (oxidation) at pH 1.5.
• The developed electrochemical method was effectively applied to analyze nifedipine in commercial tablets and capsules.

Conclusions:

• A sensitive and reliable electrochemical method for nifedipine determination has been established.
• The new pre-treatment of the glassy carbon electrode enhances the analytical performance.
• This method offers a viable approach for the quality control of nifedipine in pharmaceutical samples.