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Application of micellar electrokinetic chromatography for analyzing antiviral drugs in pharmaceutical semisolid
R H Neubert1, Y Mrestani, M Schwarz
1Institute of Pharmaceutics and Biopharmaceutics, Martin-Luther-University, Halle/Saale, Germany.
Journal of Pharmaceutical and Biomedical Analysis
|April 16, 1998
Abstract:
The application of micellar electrokinetic chromatography (MEKC) to the determination of the antiviral drugs brivudin (BV) and aciclovir (AC) in pharmaceutical semisolid formulations was studied. A method was developed for separating AC and BV both from hydrophilic and from lipophilic semisolid formulations and for the rapid determination of BV and AC using MEKC. The detection limit, the effective mobility and the relative standard deviation of the migration times and of the peak areas were determined.