Changes in cerebral blood flow velocities during childhood absence seizures

A simultaneous recording of mean flow velocity in the right middle cerebral artery by transcranial Doppler ultrasonography and electroencephalographic activity was performed in 5 children with multiple daily typical absence seizures. Twenty-eight absence episodes were recorded. Mean flow velocity increased gradually a few seconds before the clinical and electroencephalographic manifestations of each seizure and reached the maximum values (range of increase: 25.5-42.8% with respect to baseline) within 2-3 seconds from their onset. This increase was then followed by a fast reduction in flow velocity, with the lowest levels (range of decrease: 30.8-44.0% with respect to baseline) recorded within 4-6 seconds from the end of each absence seizure. These findings suggest that changes in cerebral blood flow and activity are quite complex during absence seizures and that they do not fully correlate with clinical and electroencephalographic manifestations.