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Isolation of a bioactive Ca(2+)-mobilizing complex lipid from bovine vitreous body
J P Camiña1, X A Casabiell, F R Pérez
1Department of Medicine, Compostela University School of Medicine, Santiago de Compostela, Spain.
Biochemical and Biophysical Research Communications
|April 16, 1998
Abstract:
Vitreous body extracts show a potent Ca(2+)-mobilizing activity on fibroblast cells. This Ca2+ signal is complex, and due to the presence of two different bioactive substances. The first one was identified as acid FGF. The second one was shown to be a low molecular weight substance identified as a complex lipid by a combination of chromatographic and biochemical data. This finding raises the possibility that non-classical substances with growth factor-like activity might play a role in the regulation of proliferative processes in the eye.