Related Experiment Videos
In vitro effect of dexamethasone phosphate on hematopoietic progenitor cells in preterm infants
P Papoff1, R D Christensen, J Harcum
1Department of Paediatrics, University of Florida College of Medicine, Gainesville, USA.
Archives of Disease in Childhood. Fetal and Neonatal Edition
|April 16, 1998
Abstract:
The in vitro effect of dexamethasone on the clonal growth of haematopoietic progenitors in preterm infants was investigated. Concentrations of 10(6)M to 10(9)M were associated with a dose dependent inhibition of colony formation, with the most clinically important effects seen on the earliest erythroid and granulocyte-macrophage colonies. Because of the potential clinical implications of these observations, studies are needed to determine the effects of dexamethasone on haematopoiesis in preterm infants.