The pattern electroretinogram in anterior visual pathway dysfunction and its relationship to the pattern visual...

The pattern electroretinogram (PERG) has now been in routine clinical use for sufficiently long to allow a personal clinical review of its relationship to the cortically generated pattern visual evoked potential (PVEP). The PERG and PVEP findings are presented from 520 eyes with optic nerve demyelination (382 eyes), optic nerve compression (90 eyes) or heredofamilial optic atrophy (48 eyes), and these are compared with the findings obtained in 223 eyes with dysfunction anterior to the retinal ganglion cells. Dysfunction anterior to the retinal ganglion cells gives a reduction in the P50 component of the PERG, but this component is usually spared in optic nerve disease where selective loss of the N95 component is by far the most frequently occurring abnormality. A diagnostic strategy is presented.