Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Do animal models have clinical value?

P J Schwartz1

  • 1Department of Cardiology, Policlinico S. Matteo IRCCS, and University of Pavia, Italy.

The American Journal of Cardiology
|April 16, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optimizing Peri-Operative Pain Management in Children With Long QT Syndrome and Catecholaminergic Polymorphic Ventricular Tachycardia Undergoing Left Cardiac Sympathetic Denervation: A Case Series on Continuous Erector Spinae Plane Block and Serratus Plane Block.

Paediatric anaesthesia·2025
Same author

Left cardiac sympathetic denervation in the Netherlands for the treatment of inherited arrhythmia syndromes.

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·2014
Same author

Vagal stimulation for heart diseases: from animals to men. An example of translational cardiology.

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·2012
Same author

Gene symbol: KCNH2. Disease: Long QT syndrome.

Human genetics·2010
Same author

Gene symbol: KCNQ1. Disease: Long QT syndrome.

Human genetics·2010
Same author

Gene symbol: KCNH2. Disease: Long QT syndrome.

Human genetics·2010

This study evaluates animal models for antiarrhythmic and antifibrillatory interventions. It stresses matching animal model results with human trials for effective clinical translation.

Area of Science:

  • Cardiovascular Research
  • Pharmacology
  • Preclinical Studies

Background:

  • Animal models are crucial for studying cardiac arrhythmias.
  • Translating findings from animal models to human clinical trials presents challenges.
  • Evaluating the predictive value of animal models is essential for drug development.

Purpose of the Study:

  • To assess the efficacy of animal models in studying antiarrhythmic and antifibrillatory interventions.
  • To highlight the importance of selecting appropriate animal models.
  • To compare animal study results with human clinical trials.

Main Methods:

  • Review and citation of specific studies using animal models for cardiac interventions.
  • Analysis of design factors including internal controls, reproducibility, and anesthesia.

Related Experiment Videos

  • Comparison of outcomes from animal studies with human clinical trial data.

    • Main Results:

    • Discussion of advantages and disadvantages of various animal model designs.
    • Evaluation of the predictive accuracy of animal models for clinical outcomes.
    • Identification of key factors influencing the translatability of animal study results.

    Conclusions:

    • Appropriate selection and validation of animal models are critical for successful antiarrhythmic and antifibrillatory research.
    • Understanding the limitations of animal models is key to accurate clinical outcome prediction.
    • Bridging the gap between preclinical animal studies and human trials is vital for advancing cardiovascular medicine.