Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vertebrate genome evolution and the zebrafish gene map

J H Postlethwait1, Y L Yan, M A Gates

  • 1Institute of Neuroscience, University of Oregon, Eugene 97403-1254, USA. jpostle@oregon.uoregon.edu

Nature Genetics
|April 16, 1998
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Observation of Seven Astrophysical Tau Neutrino Candidates with IceCube.

Physical review letters·2024
Same author

Lost gallstones during laparoscopic cholecystectomy as a common but underestimated complication-case report and review of the literature.

Frontiers in surgery·2024
Same author

Achievement of Target Gain Larger than Unity in an Inertial Fusion Experiment.

Physical review letters·2024
Same author

19-month follow-up survey on women with atopic eruption of pregnancy postpartum: An encouraging outlook.

The Journal of dermatology·2024
Same author

A Comparative Study of Deep Learning Methods for Multi-Class Semantic Segmentation of 2D Kidney Ultrasound Images.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2023
Same author

Observation of high-energy neutrinos from the Galactic plane.

Science (New York, N.Y.)·2023

Two genome duplication events likely occurred before the divergence of fish and mammals, driving vertebrate evolution. This study mapped zebrafish genes to support this polyploidization hypothesis.

Area of Science:

  • Evolutionary biology
  • Genomics
  • Comparative genomics

Background:

  • Chordate evolution involved significant changes in nervous system, jaws, and appendages, potentially driven by gene duplication.
  • Previous hypotheses on vertebrate gene duplication events include one or two rounds of polyploidization, with debate on their timing relative to fish divergence.
  • Distinguishing between tandem duplications and polyploidization, and identifying lineage-specific duplications, remains challenging.

Purpose of the Study:

  • To investigate the number and timing of early genome duplication events in vertebrate evolution.
  • To differentiate between polyploidization and other duplication mechanisms using comparative gene mapping.
  • To establish a zebrafish gene map for functional genomics studies and human gene function inference.

Main Methods:

Related Experiment Videos

  • Construction of a gene map for 144 zebrafish genes.
  • Comparison of the zebrafish gene map with existing mammalian chromosome maps.
  • Analysis of conserved chromosome segments between zebrafish and mammals.

Main Results:

  • Identification of large conserved chromosome segments between zebrafish and mammals.
  • Observation that duplicated chromosome segments in zebrafish frequently correspond to specific mammalian chromosome segments.
  • Strong evidence supporting two rounds of polyploidization prior to the fish-mammal lineage split.

Conclusions:

  • Two rounds of whole-genome duplication (polyploidization) likely preceded the divergence of the fish and mammal lineages.
  • The zebrafish gene map provides a valuable resource for identifying gene functions and understanding evolutionary relationships.
  • Comparative genomics supports polyploidization as a key mechanism for innovation in early vertebrate evolution.