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SKF 38393 enhances odor detection performance

R L Doty1, C Li, R Bagla

  • 1Smell and Taste Center, Hospital of the University of Pennsylvania, and Department of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, Philadelphia 19104, USA.

Psychopharmacology
|April 16, 1998
PubMed
Summary
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The D1 receptor agonist SKF 38393 significantly improved odor detection performance in rats. This enhancement was dose-dependent and blocked by the D1 antagonist SCH 23390, unlike the D2 agonist quinpirole.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Behavioral Science

Background:

  • Dopamine receptor agonists differentially affect cognitive functions.
  • D2 receptor agonists like quinpirole impair odor detection performance.
  • The role of D1 receptor activation in olfactory processing remains largely uncharacterized.

Purpose of the Study:

  • To investigate the influence of the D1-selective partial agonist SKF 38393 on rat odor detection performance.
  • To compare the effects of D1 receptor activation with previously observed D2 receptor effects on olfaction.

Main Methods:

  • Utilized high-precision olfactometry and a go/no-go operant task in rats.
  • Administered varying intraperitoneal doses of SKF 38393 (1.0–12.5 mg/kg).
  • Tested responses to ethyl acetate and eugenol, and assessed blockade with D1 antagonist SCH 23390.

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Main Results:

  • SKF 38393 dose-dependently enhanced odor detection performance for ethyl acetate in male rats at 7.5 and 10.0 mg/kg.
  • This enhancement was replicated and extended to 12.5 mg/kg, and observed for eugenol in female rats.
  • The D1 antagonist SCH 23390 attenuated the performance-enhancing effects of SKF 38393.

Conclusions:

  • D1 receptor activation by SKF 38393 improves odor detection performance in rats.
  • This effect is dose-dependent, not sex-specific, and not limited to a single odorant.
  • D1 receptor agonism offers a contrasting mechanism to D2 receptor agonism in modulating olfactory function.