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[Epstein-Barr virus and cellular immortalization]

V Marechal¹, A Dehée, J C Nicolas

¹Service de Microbiologie, Hôpital Rothschild, Paris.vmarechal@infobiogen.fr

Annales De Medecine Interne

|January 1, 1997

Abstract:

Epstein-Barr virus has been associated to several forms of neoplasia including Burkitt's lymphoma, B lymphomas in immuno-compromised patients and undifferentiated nasopharyngeal carcinoma. Immunodepression, genetic and/or environmental factors and the expression of several viral genes (latent genes mainly) may contribute to these pathologies. In vitro, several latent proteins (EBNA 1, 2, 3A, 3C, 5 et LMP-1) directly or indirectly contribute to the initiation and maintenance of the transformation process. The role of these proteins is discussed in the present article.

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