Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antisense peptides: a critical mini-review

R S Root-Bernstein1, D D Holsworth

  • 1Department of Physiology, Michigan State University, Lansing 48824, USA.

Journal of Theoretical Biology
|April 16, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Therapeutic AIDS vaccines.

Current pharmaceutical design·2006
Same author

Antioxidant-independent ascorbate enhancement of catecholamine-induced contractions of vascular smooth muscle.

American journal of physiology. Heart and circulatory physiology·2004
Same author

Steric hindrance as a basis for structure-based design of selective inhibitors of protein-tyrosine phosphatases.

Biochemistry·2001
Same author

Insulin binds to glucagon forming a complex that is hyper-antigenic and inducing complementary antibodies having an idiotype-antiidiotype relationship.

Autoimmunity·2001
Same author

Natural electrophoresis of norepinephrine and ascorbic acid.

Biophysical journal·2000
Same author

Toward a philosophy of cancer research.

Anticancer research·2000

Antisense peptides, derived from DNA's non-coding strand, show biological activity but their mechanisms remain controversial. Future research should clarify their specificity and interactions using advanced techniques.

Area of Science:

  • Molecular Biology
  • Biochemistry
  • Genetics

Background:

  • Antisense peptides are analogs to antisense RNA technologies.
  • They are generated from the non-coding strand of DNA.
  • Biological activity has been observed for peptides derived from both parallel and anti-parallel readings.

Purpose of the Study:

  • Critically review key data and issues in the emerging field of antisense peptides.
  • Focus on contradictions and discrepancies in current studies.
  • Suggest future research directions.

Main Methods:

  • Literature review of existing studies on antisense peptides.
  • Analysis of contradictory findings and mechanistic controversies.
  • Proposal for future research methodologies.

Related Experiment Videos

Main Results:

  • Significant controversy exists regarding the mechanisms of antisense peptide action.
  • Current studies present contradictions and discrepancies.
  • The field is emerging with a need for further investigation.

Conclusions:

  • Antisense peptides represent a novel area with potential biological significance.
  • Further physico-chemical studies are needed to elucidate their mechanisms.
  • Combinatorial chemistry and solid-phase binding assays can help determine interaction specificity.