[Plasma serine protease inhibitors in dialyzed patients with chronic renal insufficiency]

In the plasma of fourty dialyzed patients with chronic renal insufficiency in comparison to controls a mild decrease of AT III activity, low activity of PAI-1 and alfa-2 AP with normal activity alfa-2 M. and alfa-1 PI were observed. Hemodialysis with the presence of heparin except of mild shortness of ELT did not influenced the activities of the inhibitors in the plasma of the patients. The decrease of PAI-1 and alfa-2 AP activity with increased FDP concentration in the dialyzed patients can suggests the occurrence of secondary fibrinolysis activation with consumption of these inhibitors.