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An atlas of serpin conformations
J Whisstock1, R Skinner, A M Lesk
1Department of Haematology, University of Cambridge, MRC Centre, UK.
Trends in Biochemical Sciences
|April 16, 1998
Abstract:
The serpins are a family of proteins that inhibit chymotrypsin-like serine proteinases, with an unusual mechanism involving a large conformational change known as the stressed-->relaxed (S-->R) transition. This article is a guide to the known serpin conformations and their biological significance.