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Related Experiment Videos

Hormone action and chromatin remodelling

D Robyr1, P Wolffe

  • 1Université de Lausanne, Institut de Biologie Animale, Bâtiment de Biologie, Switzerland. awlme@helix.nih.gov

Cellular and Molecular Life Sciences : CMLS
|April 16, 1998
PubMed
Summary

This review explores how nuclear receptors interact with chromatin, influencing gene expression through coactivators and corepressors. Nucleosome positioning and histone modifications are key regulators of this transcriptional control process.

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Area of Science:

  • Molecular Biology
  • Genetics
  • Epigenetics

Background:

  • Transcriptional regulation involves coactivators and corepressors mediating interactions between transcription factors, basal machinery, and chromatin.
  • Nuclear and steroid hormone receptors are well-characterized transcription factors utilizing these coactivators and corepressors.

Purpose of the Study:

  • To review the mechanisms by which nuclear receptors access chromatin.
  • To examine chromatin structure modifications instigated by nuclear receptors.
  • To discuss the implications for transcriptional control.

Main Methods:

  • Literature review focusing on nuclear receptors and chromatin interactions.
  • Analysis of existing research on coactivator/corepressor function.

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  • Synthesis of findings on chromatin remodeling and gene expression.

    • Main Results:

    • Nuclear receptors gain access to chromatin through specific mechanisms.
    • Receptor binding leads to targeted modifications of chromatin structure.
    • These modifications significantly impact gene expression levels.

    Conclusions:

    • Nucleosome positioning is a critical factor in regulating gene accessibility.
    • Targeted histone modifications play a central role in controlling gene expression.
    • Understanding these processes is vital for comprehending transcriptional regulation.