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Related Experiment Videos

Cognitive function in an elderly population with persistent impaired glucose tolerance

M Vanhanen1, K Koivisto, J Kuusisto

  • 1Department of Neurology, Kuopio University Hospital, Finland. matti.vanhanen@uku.fi

Diabetes Care
|April 16, 1998
PubMed
Summary

Persistent impaired glucose tolerance (IGT) in older adults is linked to reduced cognitive function. Higher insulin levels may explain this association, impacting memory and mental state.

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Area of Science:

  • Gerontology
  • Neuroscience
  • Metabolic Health

Background:

  • Impaired glucose tolerance (IGT) is a common condition in aging populations.
  • Cognitive decline is a significant concern in the elderly.
  • The relationship between persistent IGT and cognitive function requires further investigation.

Purpose of the Study:

  • To investigate cognitive function in elderly individuals with persistent impaired glucose tolerance (IGT).
  • To explore potential metabolic factors, such as insulin levels, associated with cognitive performance in this group.

Main Methods:

  • A population-based sample of 1,300 individuals was assessed for glucose and insulin levels.
  • 980 subjects were re-evaluated after an average of 3.5 years, with cognitive function assessed using a neuropsychological test battery.

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  • Analysis included subjects with persistent normal glucose tolerance (NGT) and persistent IGT.

    • Main Results:

    • Elderly individuals with persistent IGT demonstrated lower scores on the Mini-Mental State Examination (MMSE) and Buschke Selective Reminding Test (long-term memory).
    • In subjects with persistent IGT, MMSE scores were significantly associated with age, education, and insulin levels (fasting or 2-hour postload).
    • Other potential risk factors for cognitive impairment were not significantly linked to MMSE scores.

    Conclusions:

    • Persistent impaired glucose tolerance (IGT) in the elderly is associated with mild cognitive impairment.
    • Hyperinsulinemia is a potential mechanism underlying the link between persistent IGT and cognitive decline in older adults.