Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Amide derivatives with H1-antihistaminic effect

C Saturnino1, P Saturnino, G De Martino

  • 1Facoltà di Farmacia, Università degli Studi di Salerno, Penta-Salerno, Italy.

Pharmaceutica Acta Helvetiae
|April 16, 1998
PubMed
Summary

Researchers synthesized N-aminoalkylacetamides and evaluated their potential as H1-antihistaminic agents. Structure-activity relationships were explored, identifying key features for effective histamine receptor blockade.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Design, synthesis and biological evaluation of multitarget hybrid molecules containing NHC-Au(I) complexes and carbazole moieties.

European journal of medicinal chemistry·2024
Same author

Modulation of gut microbiota in patients with IBS and systemic nickel allergy after diet and probiotic supplementation: a pilot study.

Journal of biological regulators and homeostatic agents·2020
Same author

Corrigendum to: Phosphonium Salt Displays Cytotoxic Effects Against Human Cancer Cell Lines.

Anti-cancer agents in medicinal chemistry·2019
Same author

Correction: Identification of the key structural elements of a dihydropyrimidinone core driving toward more potent Hsp90 C-terminal inhibitors.

Chemical communications (Cambridge, England)·2016
Same author

Identification of the key structural elements of a dihydropyrimidinone core driving toward more potent Hsp90 C-terminal inhibitors.

Chemical communications (Cambridge, England)·2016
Same author

Light-dependent effects of alpha-terthienyl in eggs, larvae, and pupae of mosquitoAedes aegypti.

Journal of chemical ecology·2013

Area of Science:

  • Medicinal Chemistry
  • Pharmacology

Background:

  • Histamine H1 receptors play a crucial role in allergic responses.
  • Development of effective H1-antihistaminic agents is essential for managing allergic conditions.

Purpose of the Study:

  • To synthesize and characterize a novel series of N-aminoalkylacetamides.
  • To investigate the structure-activity relationships (SAR) of these compounds as H1-antihistaminic agents.
  • To evaluate the in vitro efficacy of synthesized compounds in blocking histamine activity.

Main Methods:

  • Chemical synthesis of N-aminoalkylacetamide derivatives.
  • In vitro pharmacological assays using isolated guinea pig ileum.
  • Measurement of inhibition of histamine-induced contractions.
  • Quantification of antagonist potency using pA2 values.

Related Experiment Videos

Main Results:

  • Successful synthesis of a series of N-aminoalkylacetamides.
  • Demonstration of H1-antihistaminic activity for the synthesized compounds.
  • Establishment of structure-activity correlations guiding further drug design.
  • Quantitative data on antagonist potency (pA2) obtained for tested agents.

Conclusions:

  • The synthesized N-aminoalkylacetamides exhibit promising H1-antihistaminic properties.
  • SAR analysis provides insights into the molecular requirements for potent H1-antagonist activity.
  • These findings support the potential development of these compounds as therapeutic agents for histamine-mediated conditions.