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Quantitation of postmortem profenofos levels

H Seno1, H Hattori, T Kumazawa

  • 1Hamamatsu University School of Medicine, Japan. sn0220@akiha.hama-med.ac.jp

Journal of Toxicology. Clinical Toxicology
|April 16, 1998
PubMed
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A case report details the fatal ingestion of profenofos, an organophosphate pesticide. Quantitation revealed high levels of profenofos in biological samples, confirming lethal poisoning.

Area of Science:

  • Toxicology
  • Analytical Chemistry
  • Forensic Science

Background:

  • Organophosphate pesticides, such as profenofos, are widely used in agriculture.
  • Accidental and intentional exposures can lead to severe poisoning and fatalities.
  • Accurate toxicological analysis is crucial for confirming cause of death.

Observation:

  • An 88-year-old female was discovered deceased under suspicious circumstances.
  • Suicidal ingestion of profenofos was suspected as the cause of death.
  • Post-mortem analysis was conducted on biological samples and gastric contents.

Findings:

  • Gas chromatography-mass spectrometry (GC-MS) identified profenofos.
  • Gas chromatography-nitrogen phosphorus detection (GC-NPD) quantitated profenofos levels.

Related Experiment Videos

  • Detected profenofos concentrations were 1200 ng/mL in whole blood, 350 ng/mL in urine, and 3.35 mg/mL in gastric contents.

    • Implications:

    • This case highlights the lethal potential of profenofos even in small quantities.
    • The analytical methods used are effective for detecting and quantifying profenofos in post-mortem toxicology.
    • Understanding toxicokinetics and lethal levels is vital for forensic investigations and clinical management of organophosphate poisoning.