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Zinc gluconate: acute ingestion

M R Lewis¹, L Kokan

¹St. Anthony Family Medicine Residency, Denver, Colorado, USA.

Journal of Toxicology. Clinical Toxicology

|April 16, 1998

Summary

Acute zinc gluconate overdose in a 17-year-old male resulted in severe nausea and vomiting. Fortunately, no long-term health issues were observed after ingesting 4g of zinc gluconate.

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Area of Science:

Toxicology
Pharmacology
Clinical Case Reports

Background:

Zinc gluconate is widely used for common cold symptom relief.
Limited data exists regarding the effects of acute zinc gluconate overdose.
Understanding overdose effects is crucial for patient safety and clinical guidance.

Observation:

A 17-year-old male ingested approximately 4g of zinc gluconate (85 tablets).
Severe nausea and vomiting occurred within 30 minutes of ingestion.
No other adverse effects like gastrointestinal bleeding, shock, or organ damage were reported.

Findings:

The patient experienced acute gastrointestinal distress following zinc gluconate overdose.
Serum zinc levels reached 4.97 mg/dL approximately 5 hours post-ingestion.
No significant sequelae were observed, indicating potential for recovery from acute overdose.

Implications:

This case highlights the acute gastrointestinal toxicity of high-dose zinc gluconate.
It suggests that severe overdose may not lead to severe systemic complications in all cases.
Further research is needed to establish safe upper limits and management protocols for zinc gluconate overdose.

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