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5HT2C CYS23/SER23 polymorphism is not associated with obsessive-compulsive disorder
M C Cavallini1, D Di Bella, L Pasquale
1Department of Neuroscience, Istituto Scientifico H San Raffaele, University of Milan Medical School, Milano, Italy.
Psychiatry Research
|April 16, 1998
Summary
This study found no link between the 5HT2C receptor gene mutation and obsessive-compulsive disorder (OCD). Further research into complex genetic models is needed to understand OCD
Area of Science:
- Neuroscience
- Genetics
- Psychiatry
Background:
- Genetic factors are implicated in obsessive-compulsive disorder (OCD).
- Serotonergic mechanisms are believed to play a role in OCD, evidenced by medication responses.
Purpose of the Study:
- To investigate the association of the Cys23Ser mutation in the 5HT2C receptor gene with OCD etiology.
- To examine if this mutation influences treatment response to clomipramine in OCD patients.
Main Methods:
- An association study comparing 109 OCD patients and 107 healthy controls.
- Analysis of allelic and genotypic associations.
- Extended analysis on a subsample of 39 OCD patients undergoing clomipramine challenge testing.
Main Results:
- No significant allelic or genotypic association was found between the Cys23Ser 5HT2C receptor gene mutation and OCD.
- The mutation was not associated with treatment response in OCD patients receiving clomipramine.
Conclusions:
- The Cys23Ser mutation of the 5HT2C receptor gene does not appear to play a specific role in the etiology of OCD.
- More complex genetic models are likely necessary to elucidate the role of serotonergic system in OCD pathogenesis.