Related Experiment Video
Updated: Aug 9, 2026

Mouse Eye Enucleation for Remote High-throughput Phenotyping
Published on: November 19, 2011
The genotype-phenotype controversy in ophthalmology. Implications of heterogeneity on diagnosis, embryology and
1Center for Handicapped Children, Gentofte, Denmark.
Abstract:
Genetic heterogeneity in ophthalmology adds a new dimension to differential diagnosis and prognosis. The indispensable clinical classification is refined by molecular genetic strategies. They sometimes build up new families of diseases, sometimes indicate that what was thought to be aetiologically related disorders are caused by different genetic mechanisms. Heterogeneity throws new light on embryological pathways, and the molecular genetics of the eye increases the information of the localisation of metabolically active substances and structural proteins in the eye.
Related Concept Videos
Genetic Lingo
Multiple Allele Traits
Pleiotropy
Incomplete Dominance
Background and Environment Affect Phenotype
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
Genetic Variation
Genes exist in different versions called alleles, which...

