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Cell adhesion molecules: an overview

J Joseph-Silverstein1, R L Silverstein

  • 1St. John's University, Jamaica, New York 11439, USA.

Cancer Investigation
|April 29, 1998
PubMed
Summary
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Recent research has significantly advanced our understanding of cell adhesion molecules, their functions, and their roles in cell signaling. Therapeutic strategies targeting these molecules show promise for treating cardiovascular diseases and cancer.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Pharmacology

Background:

  • Extensive research over the past two decades has elucidated the structure and function of numerous cell adhesion molecules.
  • These molecules have been classified based on structural features, ligand binding, and expression patterns.
  • Current research emphasizes the interaction of cell adhesion molecules with intracellular components and their role in cell signal transduction.

Purpose of the Study:

  • To review the current knowledge on cell adhesion molecules.
  • To highlight the therapeutic potential of targeting cell adhesion molecules in clinical medicine.
  • To discuss ongoing developments in adhesion-based therapies for various diseases.

Main Methods:

  • Literature review of basic and clinical research on cell adhesion molecules.

Related Experiment Videos

  • Analysis of identified adhesion molecules, their structures, ligands, and expression.
  • Examination of studies on cell adhesion molecule interactions with intracellular components and signal transduction pathways.
  • Review of pharmacological approaches, including approved drugs and therapies under development.

    • Main Results:

    • Numerous cell adhesion molecules have been identified and characterized.
    • Cell adhesion molecules play critical roles in cell signaling and intracellular communication.
    • Abciximab (Reopro), an inhibitor of platelet integrin alpha IIb beta 3, is approved for improving vessel patency post-angioplasty.
    • Adhesion-based therapies are being developed to target angiogenesis, tumor progression, and metastasis.

    Conclusions:

    • Targeting cell adhesion molecules offers significant therapeutic promise for various medical conditions.
    • Pharmacological agonists and antagonists for adhesion molecules are under development.
    • Adhesion-based therapies hold potential for cancer treatment and management of other diseases.