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CD44v6 is not a prognostic factor in primary breast cancer
R H Jansen1, S R Joosten-Achjanie, J W Arends
1Department of Internal Medicine, University Hospital Maastricht, The Netherlands.
Background:
CD44 is an adhesion molecule and represents a highly variable family of isoforms. The isoform CD44v6 has been associated with metastasis formation and poor prognosis in animal models and human colon cancer. Results of studies in primary breast cancer are relatively small and contradictory.
Patients And Methods:
The immunohistochemical expression of CD44v6 was studied in a series of 338 patients with primary breast tumours, uniformly staged and treated in a single center with a long median follow-up of 128 months. The prognostic significance of CD44v6 as well as the correlation with several clinicopathological features were analysed.
Results:
Two hundred nineteen of 338 (64.8%) of the breast cancer were CD44v6-positive (> 5% of tumour cells with positive staining). CD44v6 expression had no value for prognosticating disease-free or overall survival at this or any other cut-off point.
Conclusion:
CD44v6 expression is not a prognostic factor in primary breast cancer.