Related Experiment Video
Updated: Aug 7, 2026

A Melanoma Patient-Derived Xenograft Model
Published on: May 20, 2019
[Kinetics of development of human melanoma xenografts in immunosuppressed animals]
L A Ostrovskaia1, N M Ul'ianova, M M Fomina
1Emanuel' Institute of Chemical Physics, Russian Academy of Sciences, Moscow, Russia.
Abstract:
An experimental model of development of the human tumor xenografts (melanomas HCMB and Bro) in immunosuppressed phenotypically normal animals (CBA/Ca mice) was developed. Optimal conditions were established for immunodeficiency induction in the animals. Kinetics of development of the xenografts in the immunosuppressed animals was studied. The level of 0(6)-alkyl-guanine-DNA-alkyltransferase, an enzyme responsible for repair of DNA damage in the tumor cells induced by chemotherapeutic agents (nitroalkylurea), was determined.

